The Municipality of Negotino covers an area of 414 km2 in the middle of the Povardarie area and in the central part of the country. It belongs to Vardar Region and as a separate natural area it belongs to Tikveš–Raečki micro region. It covers the eastern part of Tikveš valley, spreading out onto the two banks of Vardar River.

It hosts 19.212 inhabitants. Most of them (13.104 / 68,2%) live in the town of  Negotino. The rest population lives in the 14 villages while three settlements remain fully depopulated.  In the business sector, 65% of the enterprises in the Municipality are registered in the sector of services with wholesale and retail trade. In the industrial production in the Municipality, the food industry has a dominant role with 50% of the total production. The construction and textile industry are following with 17% and 12,5% relatively. The total unemployed population is about 7%.

The Municipality of Negotino has 52 employees in three sectors (Legal and general affairs and public Issues, Financial affairs, Urbanism and protection of environment, communal work and traffic and local economic development). Its goal is the further development of the Municipality in terms of public infrastructure and economic progress.